NCLEX® Endocrine
Practice Questions
Try NCLEX Endocrine Practice Questions
Test your endocrine knowledge with this nursing endocrine quiz. To experience UWorld's official questions, with detailed visual rationales for every answer choice. See our full library of free NCLEX practice questions.
Priority question - Recognizing the priority intervention for hypoglycemia
The nurse enters a client’s room and observes that the client is diaphoretic, lethargic, and disoriented to place and time.
Which of the following actions would be a priority for the nurse to take?
| 1. Administer IM glucagon. | |
| 2. Administer IV regular insulin. | |
| 3. Prepare the client for a CT scan. | |
| 4. Obtain the client’s capillary blood glucose level. |
Intervene question - Client with CKD prescribed metformin
The nurse is reviewing new prescriptions for a client with diabetes mellitus and end-stage renal disease.
The nurse should clarify the prescription for
| 1. metformin | |
| 2. erythropoietin | |
| 3. acetaminophen | |
| 4. phosphate binder |
Plan of care question - Teaching a client with DM (type II) who is newly insulin dependent
The nurse is teaching the client with newly diagnosed type 1 diabetes mellitus how to manage their condition at home.
Which of the following interventions should the nurse include in the client’s plan of care? Select all that apply.
| 1. Teach the client to rotate injection sites when administering insulin. | |
| 2. Instruct the client to limit oral intake if the capillary blood glucose level is elevated. | |
| 3. Remind the client that fruits and vegetables do not need to be included when counting carbohydrates. | |
| 4. Instruct the client to check the capillary blood glucose level before meals and at bedtime. | |
| 5. Demonstrate to the client how to visually inspect the feet daily. |
Medication/Risk factor/Manifestation question - Long acting insulin duration/properties
The nurse is talking with a client with diabetes mellitus who is receiving insulin lispro and insulin glargine.
Which of the following statements by the nurse would require follow-up?
| 1. “Insulin glargine reduces your risk of developing diabetic ketoacidosis.” | |
| 2. “I will wait to administer your insulin lispro until your meal tray arrives.” | |
| 3. “Insulin lispro dosing depends on the number of carbohydrates you consume.” | |
| 4. “I will check your capillary blood glucose level 1 hour after you receive insulin glargine.” |
Teaching question - Insulin administration teach back
The nurse has taught a client with diabetes mellitus who has a new prescription for insulin.
Which of the following statements by the client would indicate a correct understanding of the teaching?
| 1. “I should immediately remove the needle after injecting the insulin.” | |
| 2. “I will shake the vial of insulin before withdrawing the medication.” | |
| 3. “The deltoid muscle is the best site to self-administer insulin.” | |
| 4. “The needle should be inserted at a 90-degree angle.” |
Priority question - Thyroid storm (finished)
The nurse is caring for a client who is experiencing thyroid storm.
It would be a priority for the nurse to
| 1. initiate beta blocker therapy | |
| 2. administer radioactive iodine | |
| 3. maintain the client on NPO status | |
| 4. place a warming blanket on the client |
Intervene question - Levothyroxine (finished)
The nurse is assessing a client with hyperthyroidism.
Which of the following findings would be consistent with hyperthyroidism?
| 1. thinning hair and cold intolerance | |
| 2. palpitations and an elevated heart rate | |
| 3. weight gain and straining with defecation | |
| 4. fatigue and prolonged menstrual periods |
Plan of care question - DI/SIADH (finished)
The nurse is planning care for a client who has diabetes insipidus.
Which of the following interventions should the nurse include in the client’s plan of care? Select all that apply.
| 1. Infuse hypotonic IV fluids. | |
| 2. Administer thiazide diuretic therapy. | |
| 3. Monitor the client’s intake and output. | |
| 4. Provide the client with high-sodium snacks. | |
| 5. Obtain a specimen to check urine specific gravity. |
Medication/Risk factor/Manifestation question - Hypothyroidism (finished)
The nurse is assessing a client with suspected hypothyroidism.
Which of the following findings would support a diagnosis of hypothyroidism? Select all that apply.
| 1. dry, brittle hair | |
| 2. unintentional weight gain | |
| 3. decreased serum T3 and T4 levels | |
| 4. decreased serum TSH level | |
| 5. heat intolerance |
Teaching question - PCOS (finished)
The nurse is teaching a client with polycystic ovarian syndrome.
Which of the following statements by the client indicate correct understanding?
| 1. “I may experience weight loss.” | |
| 2. “Oral contraceptive use should be avoided.” | |
| 3. “My ability to become pregnant may be affected.” | |
| 4. “I have a decreased risk for developing diabetes mellitus.” |
Watch Expert NCLEX Endocrine Question Breakdowns
Watch our expert nursing educators break down high-yield endocrine NCLEX questions step by step. See exactly how to read the clinical scenario, distinguish between similar endocrine disorders and apply clinical judgement to thyroid, adrenal, and pituitary questions.
What Should You Teach a Newly Diagnosed Type 1 Diabetes Patient? (SATA)
Which Insulin Statement Requires Follow-Up?
What’s the Priority Action When Giving Insulin Aspart?
Which Finding Indicates Hyperthyroidism?
Which Findings Support Hypothyroidism? (SATA)
How to Answer NCLEX Endocrine Questions
You don't need to memorize every hormone and feedback loop. You need a repeatable system for reasoning through any endocrine question the NCLEX puts in front of you.
Join the 98% Who Pass the First Time With UWorld
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Frequently Asked Questions (FAQs)
Who writes UWorld's endocrine NCLEX questions?
Every UWorld question is crafted through a rigorous, multi-step authoring process. A dedicated team of over 40+ practicing nurses and nurse educators writes, reviews, and continuously updates each item to ensure it meets strict NCSBN standards and matches the difficulty of the actual exam.
Our clinical team also works alongside professional designers with advanced degrees to create the medical illustrations and visuals that accompany each explanation. The result is a QBank that doesn’t just test you, it teaches you the clinical reasoning behind every answer.
How much is the endocrine system tested on the NCLEX?
Endocrine disorders fall under the “Physiological Adaptation” and “Reduction of Risk Potential” categories of the official NCLEX test plan. Thyroid dysfunction, adrenal disorders, and pituitary conditions are among the most commonly tested medical-surgical topics. Endocrine concepts also appear frequently in NGN Unfolding Case Studies that integrate assessment findings, lab interpretation, and medication management across multiple clinical time points.
What are the most important endocrine topics to know for the NCLEX?
Focus on the high-yield pairs: hypothyroidism vs. hyperthyroidism (including thyroid storm and myxedema coma), Addison’s disease vs. Cushing’s syndrome, and SIADH vs. diabetes insipidus. Beyond those, know growth hormone disorders, pheochromocytoma, and the key endocrine medications: levothyroxine, methimazole, hydrocortisone, desmopressin, and fluid management strategies for sodium imbalances.
What is the best way to study endocrine content for the NCLEX?
The most effective approach is mastering the “hypo vs. hyper” framework first. Understand what happens when a gland overproduces or underproduces its hormone, then learn the labs and manifestations that distinguish each state. From there, practice with NCLEX-style endocrine questions that force you to apply that reasoning in clinical scenarios. Focus on priority interventions and crisis management rather than memorizing normal hormone ranges alone. That’s what the NCLEX actually tests.
What makes UWorld's endocrine questions different from other QBanks?
Three things. First, every question comes with an in-depth explanation that covers every answer choice, correct and incorrect, so you understand the reasoning, not just the answer.
Second, our questions are written to match the difficulty and clinical judgment demands of the actual NCLEX, not simplified recall questions.
Third, our explanations include professionally designed medical illustrations that visualize hormonal feedback loops, gland anatomy, lab value relationships, and the pathophysiology of endocrine disorders, the kind of context that makes endocrine nursing click instead of requiring brute-force memorization.
How many endocrine questions does UWorld's QBank include?
UWorld’s NCLEX QBank includes hundreds of endocrine questions spanning thyroid disorders, adrenal conditions, pituitary dysfunction, parathyroid imbalances, and related endocrine medications. You can filter by endocrine specifically when creating custom practice tests, making it easy to target endocrine knowledge as a focused study area or drill into a specific disorder you’re struggling with.
Does UWorld cover Next Generation NCLEX (NGN) question types for endocrine content?
Yes. Our QBank includes every NGN item type: Unfolding Case Studies, Bow-tie, Matrix, Extended SATA, Drag-and-Drop, Drop-Down, Highlight, and Trend questions, across all subjects including endocrine. You’ll practice the exact question formats you’ll face on exam day, with the same partial-credit scoring the real NGN uses.
How does partial credit work on NGN endocrine questions?
The Next Generation NCLEX uses a plus/minus (+/−) scoring model for Select All That Apply (SATA) and other scored NGN item types. You earn points for correct selections and lose points for incorrect ones. The lowest possible score on any individual item is zero. You cannot receive a negative score.
How do I tell the difference between similar endocrine disorders on the NCLEX?
The NCLEX frequently tests look-alike endocrine conditions. The key is anchoring to the defining lab or manifestation: SIADH presents with dilutional hyponatremia and fluid retention, while diabetes insipidus presents with hypernatremia and massive urine output. Addison’s features hypotension and hyperpigmentation; Cushing’s features hypertension and a moon face. Build a comparison table of opposites and the exam questions become much more manageable.
Can I use UWorld to focus specifically on endocrine content?
Yes. UWorld lets you create unlimited custom practice tests filtered by subject, body system, question status, and difficulty level. Select “Endocrine” to generate a practice test made entirely of endocrine-related questions, or combine it with additional filters (e.g., Endocrine + Pharmacology) to drill into the exact intersection you need.
Does UWorld offer a free trial for NCLEX endocrine practice?
Yes. UWorld offers a 7-day free trial that includes 50 exam-style NCLEX practice questions with full in-depth explanations and access to review videos: no credit card required. It’s the fastest way to experience how UWorld teaches endocrine nursing differently.
*98% of UWorld NCLEX-RN Review users who completed at least 75% of the QBank passed the NCLEX-RN the first time.